Handbook of Pharmaceutical Excipients. Describes the chemical and physical properties of pharmaceutical excipients. Each monograph contains nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology. Online shopping from a great selection at Books Store. Focus On: Pharmaceutical Industry: Medication, Clinical Trial, Generic Drug, Verification and Validation, Corrective and preventive Action, Excipient. 21 CFR Part 11, Drug Development, etc. Free Download of Handbook of Pharmaceutical Excipients (Sixth Edition) pdf e-book.Edited By Raymond C Rowe, Paul J Sheskey & Marian E Quinn. You can get the soft copy of this book through the following link.
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Book reviews / Journal of Controlled Release 71 (2001) 351 – 355
erties is extensively described, however I wonder whether a graduate student with a background in biology will be able to follow the discussion without resorting to additional textbooks. A very brief, and in my opinion superficial, description of histological properties of different tissues concludes this section. Various methods for determining molecular weight, aggregation (self-assembly) and mechanical properties of macromolecules are then discussed using collagen as an example. This approach reflects the preference of the authors due to their long standing experience in this field of research, however neglects more recent developments in characterizing macromolecules. Response to tissue injury and wound healing are then discussed as core issues for the understanding of interactions between foreign material and the host. The way in which the material is presented is a little bit confusing because elementary facts of biochemistry, cell and molecular biology are mixed with complicated biological pathways. The interested reader is frequently left alone with an uncritical enumeration of possible factors and effects without direct connection to the subjects biomaterials and / or biocompatibility. The final chapters cover tissue engineering and pathobiological responses to implants highlighting the problematic issues around injectable silicone breast implants, inflammation induced by wear particles in hip and knee prostheses, and restenosis after vascular stenting. These examples make very interesting case studies for the use of implanted materials and their clinical use. In the case of tissue engineering artificial skin, replacement of cartilage / bone and liver tissue engineering are presented. Again very suitable examples for more detailed course work. The book is intended for graduate students and biomaterials scientists entering the field and the authors wanted to present an overview covering all the information necessary for an understanding of biocompatibility in one text. This goal seems to be very ambitious and I suspect that for most novices to the field of biocompatibility more than one textbook will be necessary to cover the basics. The book has also several weak-points which should be pointed out. It is difficult to understand why a textbook that carries ‘‘biocompatibility’’ in its title does not contain a single definition of this term
nor a hint in the index. Strategies and guidelines for biocompatibility testing of biomaterials have been omitted for unclear reasons. Biodegradable biomaterials and their biocompatibility are also not included in this text. Finally the latest references for suggested reading are from 1996, the majority dates back to the 80s and earlier. In a rapidly developing field such biomaterials and biocompatibility this can be problematic. Although the aim of a ‘‘one source textbook’’, was too ambitious, the book may be worth reading and having for those biomaterials scientists with a strong interest in collagen. Thomas Kissel Philipps University Marburg Department of Pharmaceutics and Biopharmacy 35032 Marburg Germany PII: S0168-3659( 01 )00240-1
Handbook of Pharmaceutical Excipients, Third Edition, Arthur H. Kibbe (ed.), Pharmaceutical Press, London, 2000, 665 pp. Since the appearance of the first edition, the Handbook of Pharmaceutical Excipients has become a book of paramount importance for people working in the field of pharmaceutical technology and formulation. It can be definitely affirmed that this is one of the books that must be present in every pharmaceutical bookshelf. In fact, this book provides a large amount of very important information concerning many aspects of excipients characteristics and use. In particular, each material is described in detail in a single monograph that reports identification items such as chemical and non proprietary name, synonyms, formula and functional category along with pharmacopeial specifications and typical properties. The method of manufacture, the stability and storage conditions are taken into account as well. Safety and handling precautions are also described. In each monograph, the definition of the pharmaceutical applications and the detailed description of
Book reviews / Journal of Controlled Release 71 (2001) 351 – 355
physico-chemical characteristics are particularly useful and very stimulating. Finally, the regulatory status and related substances are presented along with a well considered list of references. With respect to the second edition, in the new edition the monographs has been extended and updated. Ten new monographs and a number of related substances have been added leading to a total of more than 200 monographs. In conclusion, this book represents a mine of extremely useful information for people involved in the area of drug delivery especially for those aiming to search new applications for materials already approved for pharmaceutical use as thus, it certainly can be of appreciable interest to the readers of this Journal. Ruggero Bettini Daniela Cocconi Department of Pharmacy University of Parma Parma Italy PII: S0168-3659( 01 )00243-7
Biorelated Polymers and Gels: Controlled Release and Applications in Biomedical Engineering, T. Okano (ed.), Academic Press, New York, 1998, 257 pages. This is an exceptional contribution by Professor Okano and associates. Okano is a leading figure of the field of biomedical hydrogels and the originator of a number of new biohydrogels that show promise in the pharmaceutical and the biomedical fields. If you want to find out the latest developments and applications of hydrogels in our field, this is an excellent reference. The style of presentation is outstanding and the seven chapters are well balanced. These days I find that many pharmaceutical scientists fail to see the unique properties of hydrogels and their unusual applications in various fields. Those who are looking for easy solutions will be disappointed. The hydrogels discussed by Okano and
353
others are not your ‘‘standard cellulose-based excipients’’. Many of them have not been accepted by FDA, at least not up to now. Yet, such polymeric matrices show unique characteristics and properties. Okano goes through a detailed analysis of their structure, properties and especially through their socalled intelligent behavior. A truly outstanding book in the field, this book is recommended to anybody working on pharmaceutical formulations or on the development of new drug delivery systems. The printing and aesthetic appearance are exceptional as with other recent products of Academic Press. Bravo! Nicholas Peppas School of Chemical Engineering Purdue University West Lafayette, IN 47907 USA PII: S0168-3659( 01 )00249-8
Encyclopedia of Controlled Drug Delivery, Volumes 1 and 2, Edith Mathiowitz, editor, John Wiley & Sons, Inc., New York, 1999, 1057 pp. This is a timely, comprehensive treatise of the science, technology, applications, economics, and regulatory approval of controlled drug delivery. The editor did an excellent job in defining the topics to be covered and in assembling an international panel of experts as authors. This authoritative compendium covers the following areas: (1) Novel polymeric materials (polyanhydrides, poly(ortho esters), polyesters, polyphosphates, polyphosphazenes, hydrogels, bioadhesive materials, and chitosan); (2) Routes of administration (parenteral, oral, rectal, buccal, ocular, nasal, pulmonary, vaginal, and transdermal); (3) Delivery systems (drug delivery to the central nervous system, osmotic pumps, microspheres, nanoparticles, liposomes, prodrugs, drug-polymer conjugates, and intelligent systems); (4) Drugs (small organic molecules, peptides, proteins, vaccines, oligonucleotides, and genes); (5) Disease states / conditions (alcoholism, cancer, cardiovascular diseases, contraception, and infections); (6) Characterization
Book reviews / Journal of Controlled Release 71 (2001) 351 – 355
erties is extensively described, however I wonder whether a graduate student with a background in biology will be able to follow the discussion without resorting to additional textbooks. A very brief, and in my opinion superficial, description of histological properties of different tissues concludes this section. Various methods for determining molecular weight, aggregation (self-assembly) and mechanical properties of macromolecules are then discussed using collagen as an example. This approach reflects the preference of the authors due to their long standing experience in this field of research, however neglects more recent developments in characterizing macromolecules. Response to tissue injury and wound healing are then discussed as core issues for the understanding of interactions between foreign material and the host. The way in which the material is presented is a little bit confusing because elementary facts of biochemistry, cell and molecular biology are mixed with complicated biological pathways. The interested reader is frequently left alone with an uncritical enumeration of possible factors and effects without direct connection to the subjects biomaterials and / or biocompatibility. The final chapters cover tissue engineering and pathobiological responses to implants highlighting the problematic issues around injectable silicone breast implants, inflammation induced by wear particles in hip and knee prostheses, and restenosis after vascular stenting. These examples make very interesting case studies for the use of implanted materials and their clinical use. In the case of tissue engineering artificial skin, replacement of cartilage / bone and liver tissue engineering are presented. Again very suitable examples for more detailed course work. The book is intended for graduate students and biomaterials scientists entering the field and the authors wanted to present an overview covering all the information necessary for an understanding of biocompatibility in one text. This goal seems to be very ambitious and I suspect that for most novices to the field of biocompatibility more than one textbook will be necessary to cover the basics. The book has also several weak-points which should be pointed out. It is difficult to understand why a textbook that carries ‘‘biocompatibility’’ in its title does not contain a single definition of this term
nor a hint in the index. Strategies and guidelines for biocompatibility testing of biomaterials have been omitted for unclear reasons. Biodegradable biomaterials and their biocompatibility are also not included in this text. Finally the latest references for suggested reading are from 1996, the majority dates back to the 80s and earlier. In a rapidly developing field such biomaterials and biocompatibility this can be problematic. Although the aim of a ‘‘one source textbook’’, was too ambitious, the book may be worth reading and having for those biomaterials scientists with a strong interest in collagen. Thomas Kissel Philipps University Marburg Department of Pharmaceutics and Biopharmacy 35032 Marburg Germany PII: S0168-3659( 01 )00240-1
Handbook of Pharmaceutical Excipients, Third Edition, Arthur H. Kibbe (ed.), Pharmaceutical Press, London, 2000, 665 pp. Since the appearance of the first edition, the Handbook of Pharmaceutical Excipients has become a book of paramount importance for people working in the field of pharmaceutical technology and formulation. It can be definitely affirmed that this is one of the books that must be present in every pharmaceutical bookshelf. In fact, this book provides a large amount of very important information concerning many aspects of excipients characteristics and use. In particular, each material is described in detail in a single monograph that reports identification items such as chemical and non proprietary name, synonyms, formula and functional category along with pharmacopeial specifications and typical properties. The method of manufacture, the stability and storage conditions are taken into account as well. Safety and handling precautions are also described. In each monograph, the definition of the pharmaceutical applications and the detailed description of
Book reviews / Journal of Controlled Release 71 (2001) 351 – 355
physico-chemical characteristics are particularly useful and very stimulating. Finally, the regulatory status and related substances are presented along with a well considered list of references. With respect to the second edition, in the new edition the monographs has been extended and updated. Ten new monographs and a number of related substances have been added leading to a total of more than 200 monographs. In conclusion, this book represents a mine of extremely useful information for people involved in the area of drug delivery especially for those aiming to search new applications for materials already approved for pharmaceutical use as thus, it certainly can be of appreciable interest to the readers of this Journal. Ruggero Bettini Daniela Cocconi Department of Pharmacy University of Parma Parma Italy PII: S0168-3659( 01 )00243-7
Biorelated Polymers and Gels: Controlled Release and Applications in Biomedical Engineering, T. Okano (ed.), Academic Press, New York, 1998, 257 pages. This is an exceptional contribution by Professor Okano and associates. Okano is a leading figure of the field of biomedical hydrogels and the originator of a number of new biohydrogels that show promise in the pharmaceutical and the biomedical fields. If you want to find out the latest developments and applications of hydrogels in our field, this is an excellent reference. The style of presentation is outstanding and the seven chapters are well balanced. These days I find that many pharmaceutical scientists fail to see the unique properties of hydrogels and their unusual applications in various fields. Those who are looking for easy solutions will be disappointed. The hydrogels discussed by Okano and
353
others are not your ‘‘standard cellulose-based excipients’’. Many of them have not been accepted by FDA, at least not up to now. Yet, such polymeric matrices show unique characteristics and properties. Okano goes through a detailed analysis of their structure, properties and especially through their socalled intelligent behavior. A truly outstanding book in the field, this book is recommended to anybody working on pharmaceutical formulations or on the development of new drug delivery systems. The printing and aesthetic appearance are exceptional as with other recent products of Academic Press. Bravo! Nicholas Peppas School of Chemical Engineering Purdue University West Lafayette, IN 47907 USA PII: S0168-3659( 01 )00249-8
Encyclopedia of Controlled Drug Delivery, Volumes 1 and 2, Edith Mathiowitz, editor, John Wiley & Sons, Inc., New York, 1999, 1057 pp. This is a timely, comprehensive treatise of the science, technology, applications, economics, and regulatory approval of controlled drug delivery. The editor did an excellent job in defining the topics to be covered and in assembling an international panel of experts as authors. This authoritative compendium covers the following areas: (1) Novel polymeric materials (polyanhydrides, poly(ortho esters), polyesters, polyphosphates, polyphosphazenes, hydrogels, bioadhesive materials, and chitosan); (2) Routes of administration (parenteral, oral, rectal, buccal, ocular, nasal, pulmonary, vaginal, and transdermal); (3) Delivery systems (drug delivery to the central nervous system, osmotic pumps, microspheres, nanoparticles, liposomes, prodrugs, drug-polymer conjugates, and intelligent systems); (4) Drugs (small organic molecules, peptides, proteins, vaccines, oligonucleotides, and genes); (5) Disease states / conditions (alcoholism, cancer, cardiovascular diseases, contraception, and infections); (6) Characterization
What Is Pharmaceutical Excipients
The Handbook of Pharmaceutical Excipients is a comprehensive guide to the uses, properties and safety of pharmaceutical excipients and is an essential reference for those involved in the development, production, control or regulation of pharmaceutical preparations.